FISIOPATOLOGIA GLOMERULONEFRITIS MEMBRANOSA PDF

During the last decade, several major breakthroughs have led to the identification of human podocyte membrane antigens. Experimental involving antipodocyte antibodies in human membranous nephropathy MN have opened a new line of thinking about this disease, relating as an autoimmune kidney disease. It has been suggested that the serum level of anti-PLA2R could be used for the diagnosis of idiopathic MN and for the monitoring of response to treatment. However, the coexistence of autoantibodies suggests a complex pathogenic pathway that involves different podocyte targets. New experimental models are needed to elucidate the appearance time and the role of each anti-podocyte antibody in MN development and progression. Key words: autoimmune diseases; glomerulonephritis membranous; receptors; phospholipase A2.

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Consultar otras publicaciones de la S. David Arroyo 1 , Carmen Mon 2. Hospital Universitario Severo Ochoa. Hay factores de agresividad propios del germen. Puede haber semilunas extracapilares, pero suelen ser escasas [39] [40]. Los vasos extraglomerulares no suelen mostrar alteraciones. El tratamiento de la GAPE es de soporte. La hematuria y la proteinuria pueden durar varios meses.

Suele ir con hematuria y proteinuria. Series recientes apuntan a un descenso en la incidencia [89]. En el caso de P. Puede ocasionar fracaso renal agudo por nefritis intersticial aguda []. La respuesta al tratamiento suele ser buena [].

Se estima una prevalencia del 3. Aunque se puede dar en cualquier paciente, se da con mayor frecuencia en la raza negra con un ratio Pude haber microhematuria y leucocituria []. La inmunofluorescencia es positiva para C3 e IgM. Los estudios con inmunosupresores son escasos, con buena respuesta a corto plazo, pero con potenciales problemas infecciosos asociados [] [] [] []. El tratamiento antiviral parece tener un efecto positivo a nivel renal [] []. La presencia de hipocomplementemia y otros marcadores inmunes es muy habitual.

El tratamiento antiviral suele producir una respuesta positiva a nivel renal. La terapia combinada con ribavirina tiene un mejor efecto combinado a nivel renal [] []. Se han reportado aproximaciones con buenos resultados con ciclofosfamida, fludarabina y rituximab [] [] [] []. ISSN: Editores Dr. Descargar PDF. Madrid Hospital Universitario Severo Ochoa. Texto completo. J Am Soc Nephrol ; 27 5 : Nadasdy T, Hebert LA. Infection-related glomerulonephritis: understanding mechanisms. Semin Nephrol ; 31 4 : Am J Kidney Dis ; 65 6 : Chapter 9: Infection-related glomerulonephritis.

Kidney Int Suppl ; 2 2 : Epidemic nephritis in Nova Serrana, Brazil. Lancet ; : The current state of poststreptococcal glomerulonephritis. J Am Soc Nephrol ; 19 10 : Pathogenesis of poststreptococcal glomerulonephritis a century after Clemens von Pirquet. Kidney Int ; 71 11 : Autoimmune sequence of streptococcal M protein shared with the intermediate filament protein, vimentin.

J Exp Med ; 2 : Nephritis-associated plasmin receptor and acute poststreptococcal glomerulonephritis: characterization of the antigen and associated immune response. J Am Soc Nephrol ; 15 7 : Kidney Int ; 68 3 : Acute glomerulonephritis, the significance of the variations in the incidence of the disease.

J Clin Invest ; 32 4 : Ahn S-Y, Ingulli E. Acute poststreptococcal glomerulonephritis: an update. Curr Opin Pediatr ; 20 2 : Atypical postinfectious glomerulonephritis is associated with abnormalities in the alternative pathway of complement.

Kidney Int ; 83 2 : The global burden of group A streptococcal diseases. Lancet Infect Dis ; 5 11 : An epidemic of acute post-streptococcal glomerulonephritis among aboriginal children. J Paediatr Child Health ; 31 3 : New trends of an old disease: the acute post infectious glomerulonephritis at the beginning of the new millenium.

J Nephrol ; 27 3 : Rodriguez-Iturbe B, Haas M. Post-Streptococcal Glomerulonephritis. Streptococcus pyogenes? Medium- and long-term prognosis of patients with acute poststreptococcal glomerulonephritis.

Nephron ; 58 4 : Significance of albuminuria in the follow-up of acute poststreptococcal glomerulonephritis. Clin Nephrol ; 41 5 : Acute postinfectious glomerulonephritis in the modern era: experience with 86 adults and review of the literature.

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A prospective study in children. N Engl J Med ; 6 : Long-term prognosis in acute glomerulonephritis. The predictive value of early clinical and pathological features observed in 65 patients.

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The diagnosis of acute glomerulonephritis. N Engl J Med ; 21 : Plasma terminal complement complexes in acute poststreptococcal glomerulonephritis. Am J Kidney Dis ; 17 3 : Diagnostic significance of hypocomplementemia. Kidney Int ; 39 5 : Activation of the lectin complement pathway in post-streptococcal acute glomerulonephritis.

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J Am Soc Nephrol ; 4 2 :

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Glomerulonefrite rapidamente progressiva

Consultar otras publicaciones de la S. David Arroyo 1 , Carmen Mon 2. Hospital Universitario Severo Ochoa. Hay factores de agresividad propios del germen. Puede haber semilunas extracapilares, pero suelen ser escasas [39] [40].

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La glomerulonefritis

Glomerulonefritis Proliferativa Extracapilar "Crescentic". Enfermedad anti-MBG - Glomerulonefritis pauciinmune. Un cuarto tipo ha sido propuesto, por algunos autores, para aquellos casos en los que se documenta coexistencia de enfermedad anti-MBG y ANCAs. Histopathologic classification of ANCA-associated glomerulonephritis. J Am Soc Nephrol. Las semilunas pueden evolucionar a fibrosis semiluna fibrosa o desaparecer por apoptosis.

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