Camfield P, Camfield C. Incidence, prevalence and aetiology of seizures and epilepsy in children. Epileptic Disord. Rozo VM, Izquierdo A. Acta Neurol Colomb. Rev Neurol Clin.
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Cognitive side effects of antiepileptic drugs are common and can negatively affect tolerability, compliance, and long-term retention of the treatment. Ketogenic diet is an effective and well-tolerated treatment for these children with refractory epilepsy without any negative effect on cognition or behavior.
Aim: To review the current state of experimental and clinical data concerning the neuroprotective and cognitive effects of the ketogenic diet in both humans and animals. Development: In different animal models, with or without epilepsy, the ketogenic diet seems to have neuroprotective and mood-stabilizing effects.
In the observational studies in pediatric epilepsy, improvements during treatment with the ketogenic diet are reported in behavior and cognitive function, particularly with respect to attention, alertness, activity level, socialization, and sleep quality.
One randomized controlled trial in patients with pediatric refractory epilepsy showed a mood and cognitive activation during ketogenic diet treatment. Conclusions: Ketogenic diet shows a positive impact on behavioral and cognitive functioning in children and adolescents with refractory epilepsy.
More specifically, an improvement is observed in mood, sustained attention, and social interaction. Title: Epilepsia, cognicion y dieta cetogenica. Los efectos adversos cognitivos de los farmacos antiepilepticos son frecuentes y pueden afectar negativamente la tolerabilidad, el cumplimiento y el mantenimiento a largo plazo del tratamiento antiepileptico. La dieta cetogenica es un tratamiento eficaz y bien tolerado para las epilepsias infantiles refractarias y no muestra efectos adversos negativos sobre cognicion o conducta.
Revisar la evidencia actual existente con respecto a los estudios experimentales y clinicos que analizan los efectos neuroprotectores y cognitivos de la dieta cetogenica, tanto en humanos como en animales de experimentacion. La dieta cetogenica muestra efectos neuroprotectores y estabilizadores del estado de animo en diversos modelos animales, con o sin epilepsia.
En un estudio aleatorizado controlado en pacientes con epilepsia infantil refractaria, la dieta cetogenica mostro una activacion evolutiva evidente sobre la cognicion y el estado de animo.
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Full-text links Cite Favorites. Abstract in English , Spanish. Similar articles Cognitive and behavioral impact of the ketogenic diet in children and adolescents with refractory epilepsy: A randomized controlled trial. IJff DM, et al. Epilepsy Behav. Epub May A 6- to month follow-up study. Ramm-Pettersen A, et al. Epub Sep PMID: The changing face of dietary therapy for epilepsy. Pasca L, et al. Eur J Pediatr.
Epub Sep 1. PMID: Review. Short-term impact of a classical ketogenic diet on gut microbiota in GLUT1 Deficiency Syndrome: A 3-month prospective observational study.
Tagliabue A, et al. Epub Dec Araya-Quintanilla F, et al. Rev Neurol. Show more similar articles See all similar articles. Chen F, et al. Front Neurol. Publication types Review Actions. Animals Actions. Child Actions. Disease Models, Animal Actions. Humans Actions. Mice Actions.
Observational Studies as Topic Actions. Quality of Life Actions. Randomized Controlled Trials as Topic Actions. Rats Actions. Rats, Inbred F Actions. Substances Monosaccharide Transport Proteins Actions.
Supplementary concepts Glut1 Deficiency Syndrome Actions. Medical Genetic Alliance. Full-text links [x] Viguera Editores, S. Copy Download.
2019, Número 1
Introduction: The ketogenic diet is a non-pharmacological treatment that has been used as a therapeutic alternative for the management of refractory epilepsy since It is a nutrition plan that is imbalanced in terms of both macro- and micro-nutrients, which can give rise to nutritional deficits in energy, proteins, minerals and vitamins, as well as an excess of lipids. There is therefore a risk of it causing undesirable side effects both at the outset and in later stages of the treatment. Development: The most frequent adverse effects that may occur either in acute form or in later stages are described, and tools that can be used in their management and prevention during treatment are proposed for paediatricians and ketogenic diet teams. Conclusions: Some adverse effects are difficult to interpret and may manifest due to involvement at different levels of the organism, thereby arousing doubts as to whether they are caused by the diet, the antiepileptic medication or by the patient's own intercurrent complications. It is important to follow the study and evaluation frequency protocol in order to detect and prevent these effects, as well as to consult reference centres in order to evaluate the cost-benefit of continuing the treatment or not. Title: Actualizacion sobre los efectos adversos durante la terapia con dieta cetogenica en la epilepsia refractaria pediatrica.
[Epilepsy, Cognition and Ketogenic Diet]