BRONQUIOS SEGMENTARIOS PDF

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The epithelium and airway smooth muscles of patients with chronic obstructive pulmonary disease COPD or bronchial asthma undergo certain structural changes that are probably related to increased expression of inflammatory molecules and cell growth factors.

Studying the relation between disease and changes in bronchial smooth muscle is difficult if investigation is restricted to samples from autopsies or thoracotomies.

This study was designed to evaluate the probability of obtaining bronchial smooth muscle by endoscopic bronchial biopsy in patients with COPD and from individuals with normal lung function, the relation of disease to bronchial epithelial histology, and the potential usefulness of studying airway muscle remodeling events..

Forty-two patients undergoing diagnostic fiberoptic bronchoscopy were enrolled. Bronchial biopsies were taken systematically from the lobar and segmental dividing ridges. The epithelial structure was analyzed by conventional histology. The smooth muscle was identified by immunohistochemistry anti-desmin antibody assay and Western-blot analysis anti-desmin, actin and myosin antibodies..

Sixty-nine percent of the biopsies contained bronchial smooth muscle. This probability was unrelated to the presence of COPD or to signs of epithelial inflammation. The fragments allowed us to use electrophoresis to identify protein structures myosin, actin, desmin involved in muscle remodeling processes.. Endoscopic biopsy of the bronchi allows us to obtain bronchial smooth muscle samples in a large percentage of patients, particularly when performed on segmental bronchi.

The technique may be useful for future studies examining the processes of airway smooth muscle remodeling.. ISSN: Fiber-optic bronchoscopic biopsy of bronchial smooth muscle. Efficacy of the technique in individuals with normal lung function and patients with COPD.

Descargar PDF. Orozco-Levi a , b , D. Moyes c , E. Balcells a , J. Palacio b , J. Lloreta d , J. Broquetas a. Hospital del Mar. Grup de Recerca de Pneumologia. Palabras clave:. Background and Objectives The epithelium and airway smooth muscles of patients with chronic obstructive pulmonary disease COPD or bronchial asthma undergo certain structural changes that are probably related to increased expression of inflammatory molecules and cell growth factors.

This study was designed to evaluate the probability of obtaining bronchial smooth muscle by endoscopic bronchial biopsy in patients with COPD and from individuals with normal lung function, the relation of disease to bronchial epithelial histology, and the potential usefulness of studying airway muscle remodeling events. Methods Forty-two patients undergoing diagnostic fiberoptic bronchoscopy were enrolled.

The smooth muscle was identified by immunohistochemistry anti-desmin antibody assay and Western-blot analysis anti-desmin, actin and myosin antibodies. Results Sixty-nine percent of the biopsies contained bronchial smooth muscle.

The fragments allowed us to use electrophoresis to identify protein structures myosin, actin, desmin involved in muscle remodeling processes. Conclusions Endoscopic biopsy of the bronchi allows us to obtain bronchial smooth muscle samples in a large percentage of patients, particularly when performed on segmental bronchi. The technique may be useful for future studies examining the processes of airway smooth muscle remodeling. Fiberoptic bronchoscopy. Buist, P.

COPD: current concepts and future prospects. Eur Respir Rev, 6 , pp. Epidemiologic evidence for different types of chronic airflow obstruction. Am Rev Respir Dis, , pp. Mullen, J. Wright, B. Wiggs, P. Pare, J. Reassessment of inflammation of airways in chronic bronchitis. Bmj, , pp. Dunnill, G. Massarela, J. A comparison of the quantitative anatomy of the bronchi in normal subjects, in status asthmaticus, in chronic bronchitis, and in emphysema. Thorax, 24 , pp. Redington, P.

Thorax, 52 , pp. Brewster, P. Howarth, R. Djukanovic, J. Wilson, S. Holgate, W. Myofibroblasts and subepithelial fibrosis in bronchial asthma.

Halayko, H. Salari, M. Xuefei, N. Markers of airway smooth muscle cell phenotype. Am J Physiol, , pp. Wiggs, C. Bosken, P. A model of airway narrowing in asthma and chronic obstructive pulmonary disease. Airway smooth muscle cells: contributing to and regulating airway mucosal inflammation?.

Eur Respir J, 15 , pp. Bosken, B. Small airway dimensions in smokers with obstruction to airflow. Ebina, T. Takahashi, T. Chiba, M. Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma. A 3-D morphometric study. Jefferey, R. Godfrey, E. Adelroth, F. Nelson, A. Rogers, S. Effects of treatment on airway inflammation and thickening of basement membrane reticular collagen in asthma. Ann Rheum Dis, , pp.

Hall, M. Use of cultured airway myocytes for study of airway smooth muscle cell phenotype. Hautamaki, R. Kobayashi, S. Macrophage elastase is required for cigarette smoke-induced emphysema in mice. Science, , pp. Martin, A. Duguet, D. The contribution of airway smooth muscle to airway narrowing and airway hyperresponsiveness in disease.

Eur Respir J, 16 , pp. Siafakas, P. Vermeire, N. Pride, P. Paoletti, J. Gibson, P. Howard, et al. Optimal assessment and management of chronic obstructive pulmonary disease. Eur Respir J, 8 , pp.

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The alveoli are located in the respiratory zone of the lungs, at the distal termination of the alveolar ducts and atria. These air sacs are the forming and termination point of the respiratory tract. They provide total surface area of about m2. A typical pair of human lungs contain about million alveoli, producing 70m2 of surface area. An adult alveolus has an average diameter of micrometres, with an increase in diameter during inhalation. The alveoli consist of an epithelial layer and extracellular matrix surrounded by capillaries.

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