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TRREE is a free and open access online training program on research ethics and regulation. It also provides access to the national regulation in the participating countries. The training is modular. It includes an introduction to research ethics module 1 , a module on the role and responsibilities of Research Ethics Committees module 2. While some modules may focus on more specific training needs of research ethics committee members, or research teams including investigators, nurses, or study coordinators, the training is open to all and may be of interest to health authorities, funding agencies and universities, as well as to political authorities, patients and the media.

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The chronic character of the disease has a significant impact on expenses borne by individual patients and by the health care system. Patients diagnosed with epilepsy need a long-term treatment, which is often expensive. In order to minimize the costs, doctors are increasingly turning to prescribing cheaper generic drugs.

Patients using drugs with a narrow therapeutic index should be careful because of differences in bioequivalence of medicinal products. It is important, then, that therapeutic decisions should not be guided chiefly by considerations of cost reduction for the patient, but first of all by possible future health effects.

Skrzypczak Z. Gidal B. Rascati K. Lewek P. Staniszewska A. Grochowska M. Kramer G. Gauthier-Lewis M. Barnes N. Evans J. MacDonald J. Berg M. Fitzgerald C.

LeLorier J. Bialer M. Kesselheim A. Andermann F. Haskins L. Mendyk A. The effects of brand-generic substitution in antiepileptic treatment Beata Tyszko, Anna Staniszewska. Abstrakt The chronic character of the disease has a significant impact on expenses borne by individual patients and by the health care system. References Skrzypczak Z.

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The effects of brand-generic substitution in antiepileptic treatment

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