Cytogenetic analysis of blast cells in childhood acute lymphoblastic leukemia has led to the recognition of specific non-random chromosomal abnormalities with prognostic value. Most patients with ALL show karyotype abnormalities, either in chromosome number ploidy or as structural changes such as translocations, inversions, or deletions. Many of these chromosomal alterations are associated with specific cytomorphological and immunological types. The greatest impact on patient management has been the finding that the cytogenetic result is an independent prognostic indicator. Certain karyotypes are associated with a favorable prognosis while others indicate a poor outcome.
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Skip to search form Skip to main content You are currently offline. Some features of the site may not work correctly. Introduccion 2. Ciclo celular 3. Alteraciones cromosomicas 3. Anomalias estructurales de los cromosomas 4. Tecnicas de estudio de los cromosomas: citogenetica 4. Citogenetica molecular hibridacion in situ con fluorescencia 4. Origen y consecuencias de las alteraciones cromosomicas 5. View PDF. Save to Library. Create Alert. Launch Research Feed. Share This Paper. References Publications referenced by this paper.
Medical Genetics Updated 3 edition. Jorde , Carey , Bamshad , White Estimates of the frequency of chromosome abnormalities detectable in unselected newborns using moderate levels of banding. Multicolor spectral karyotyping of human chromosomes. Molecular studies of chromosomal mosaicism: relative frequency of chromosome gain or loss and possible role of cell selection. Wendy P. Schinzel Biology, Medicine American journal of human genetics Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors.
Skip to search form Skip to main content You are currently offline. Some features of the site may not work correctly. Introduccion 2. Ciclo celular 3.
Bases cromosómicas de las alteraciones genéticas humanas