Killing cancer cells through the induction of apoptosis is one of the main mechanisms of chemotherapy. However, numerous cancer cells have primary or acquired apoptosis resistance, resulting in chemoresistance. In this study, using a novel chalcone derivative chalcone Chal , we identified a novel anticancer mechanism through autophagy-mediated necroptosis RIP1- and RIP3-dependent necrosis. Chal potently killed different cancer cells with induction of necrotic cellular morphology while causing no detectable caspase activation. Blocking the necroptosis pathway with either necrostatin-1 or by knockdown of RIP1 and RIP3 effectively blocked the cytotoxicity of Chal, suggesting that Chalinduced cell death is associated with necroptosis. Importantly, suppression of autophagy, with either pharmacological inhibitors or siRNAs targeting the essential autophagy components ATG7 and Beclin1, effectively attenuated Chalinduced cell death.
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Originally a modest-sized airport, the facility grew considerably in size in the post-independence period after numerous successive renovation projects. With the outbreak of the civil war in , Aden Adde International's flight services experienced routine disruptions. However, with the security situation in Mogadishu greatly improved in the late — period, large-scale rehabilitation of the grounds' infrastructure and services once again resumed.
By early , the airport had restored most of its facilities and introduced several new features. Mogadishu airport was established in with the name Petrella-Mogadiscio aeroporto , the first such facility to be opened in the Horn of Africa. It served as the main military airport for Italian Somaliland. In the mids, the airport began offering civilian and commercial flights. A regular Asmara - Assab -Mogadishu commercial route was started in , with an Ala Littoria Caproni providing hour flights from the Mogadishu airport to Italian Eritrea.
The aircraft had a maximum capacity of 18 passengers, a record capacity at that time. The voyage lasted four days and was one of the first long range flights in the world.
During the post-independence period, Mogadishu International Airport offered flights to numerous global destinations. In the s, Somalia's then ruling socialist government enlisted its Soviet allies for major renovations to the ground's facilities. The airport's capacity to cater to both civilian and military needs was in the process significantly enlarged.
The SAC maintained a military academy at the airport that was used by all air force members. In the s, the Somali federal government recruited the U. Navy , its new Cold War partner, to further enlarge the Mogadishu airport. The project included the construction of a modern control tower equipped with state-of-the-art navigational technology.
The agreement stipulated that the company would build a second terminal for international routes as well as a new control tower. The Italian firm was also tasked with supplying air traffic control equipment.
With the collapse of the Siad Barre regime and the ensuing civil war , the airport's ongoing renovations came to a halt. Aviation operations also routinely experienced disruptions and the airport's grounds incurred significant damage. On 3 August , African Express Airways became the first international airline to resume regular flights to Mogadishu International Airport. On 20 August , the Aden Adde International Airport hosted the swearing in ceremony for many legislators in the nation's new Federal Parliament.
In , the International Civil Aviation Organization officially removed the airport from its Zone 5 list of airports deemed security risks. In late , SKA Air and Logistics, a Dubai -based aviation firm that specializes in conflict zones, was contracted by the Transitional Federal Government to manage operations over a period of ten years at the re-opened Aden Adde International Airport.
The company was assigned the task of running security screening, passenger security and terminals. The company also assisted in comprehensive infrastructure renovations, restored a dependable supply of electricity, revamped the baggage handling facilities as well as the arrival and departure lounges, put into place electronic check-in systems, and firmed up on security and work-flow.
In December , the Turkish government unveiled plans to further modernize the airport as part of Turkey 's broader engagement in the local post-conflict reconstruction process. Among the scheduled renovations are new systems and infrastructure, including a modern control tower to monitor the airspace. The firm announced plans to renovate the aviation building and construct a new one, as well as upgrade other modern service structures.
The new institution would serve to enhance the capacity of aviation personnel working in Somalia's airports, and would focus training within the country. Construction of a new terminal was scheduled to take six months, and is expected to improve the airport's functionality and operations.
In November , Favori announced that the modernization of the airport was almost finished, and was predicted to be completed by the end of Among the facilities being renovated are transit hubs and runways. The facility was built by Kozuva, a private Turkish construction firm.
In January , a new airport immigration building was opened. With assistance provided by Japan through the International Organisation for Migration IOM , it features offices, training facilities, and staff accommodation for early shift workers.
Additionally, the IOM has helped firm up on airport security by training 84 civil aviation, immigration, finance and customs department officers on proper border management and immigration protocol. It also installed its patented Personal Registration and Identification System at both Aden Adde and the capital's seaport. From Wikipedia, the free encyclopedia. For other uses, see HCMM disambiguation. Not to be confused with Aden International Airport. This article needs additional citations for verification.
Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. Source: WAD . World Airport Codes. Archived from the original on 21 October Retrieved 21 October World Aero Data. Retrieved 2 March Il Postalista. Archived from the original on 9 March Retrieved 7 October Times News. Retrieved 10 September Archived from the original on 9 May Office of the Somali Parliament.
Archived from the original on 14 July Retrieved 24 August Forum on China-Africa Cooperation. Archived from the original on 14 October Retrieved 2 October Retrieved 8 July Archived from the original on 19 January Archived from the original on 10 September Shabelle Media Network. Archived from the original on 10 March Retrieved 9 January Archived from the original on 15 January Archived from the original on 12 January Retrieved 11 January Archived from the original on 25 April Retrieved 25 April Archived from the original on 4 March Retrieved 24 November World Bulletin.
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Fuel-resistant asphalt makes airport pavements more spill-resistant
Originally a modest-sized airport, the facility grew considerably in size in the post-independence period after numerous successive renovation projects. With the outbreak of the civil war in , Aden Adde International's flight services experienced routine disruptions. However, with the security situation in Mogadishu greatly improved in the late — period, large-scale rehabilitation of the grounds' infrastructure and services once again resumed. By early , the airport had restored most of its facilities and introduced several new features. Mogadishu airport was established in with the name Petrella-Mogadiscio aeroporto , the first such facility to be opened in the Horn of Africa. It served as the main military airport for Italian Somaliland. In the mids, the airport began offering civilian and commercial flights.
Aden Adde International Airport
Harare IAP. Naypyitaw IAP. Port Harcourt IAP. Aden IAP. Wang, W. Ju, J.
Apoptosis is suppressed in cancer tissues and tumor cell lines because anti-apoptosis genes are over- expressed. The inhibitor of apoptosis proteins IAP gene family contributes to control of apoptosis. The expression profile of eight genes of the IAP family in biopsies from patients with a history of bladder cancer and normal bladder tissues, as well as a bladder tumor cell line , was assessed in the present study. Cancer tissue samples were obtained at surgery and the tumor cell line was cultured in RPMI medium. Beyond tumor margins were selected as normal tissue.